Cell-surface receptors on macrophages and dendritic cells for attachment and entry of influenza virus

Abstract

Airway MFF{cyrillic} and DCs are important components of innate host defense and can play a critical role in limiting the severity of influenza virus infection. Although it has been well established that cell-surface SA acts as a primary attachment receptor for IAV, the particular receptors) or coreceptor(s) that mediate IAV entry into any cell, including MFF{cyrillic} and DC, have not been clearly defined. Identifying which receptors are involved in attachment and entry of IAV into immune cells may have important implications in regard to understanding IAV tropism and pathogenesis. Recent evidence suggests that specialized receptors on MFF{cyrillic} and DCs, namely CLRs, can act as capture ..